Washington University in St. Louis

David Holtzman is Professor, scientific director of the Hope Center for Neurological Disorders, Co-Director of the Knight ADRC, and former Chair of Neurology at Washington University. Some of his lab’s accomplishments include showing in part how APOE contributes to AD, development of plasma and CSF biomarkers for AD, demonstration that synaptic activity and sleep affect Aβ and tau levels in vivo, describing the effects of APOE, TREM2, and both the innate and adaptive immune response on tau-mediated neurodegeneration. Several of his honors include being a recipient of the Potamkin prize and MetLife award for research on Alzheimer’s disease, Rainwater Prize for outstanding innovation in neurodegenerative disease research, election to the National Academy of Medicine, and being appointed to the National Advisory council of the NINDS and NIA. Holtzman has trained over 70 graduate students, post-doctoral fellows, many of whom have gone on to successful careers in academia and industry.