University of Pennsylvania

Dan completed his PhD in Neuroscience at Northwestern University Mesulam Center for Cognitive Neurology and Alzheimer’s Disease investigating the cellular and pathologic determinants of MRI-based cortical atrophy in the aphasic variant of Alzheimer's disease. At the University of Pennsylvania Frontotemporal Degeneration Center and the Digital Neuropathology Lab, Dan is currently interested in identifying the most vulnerable brain regions and cell types to abnormal protein deposits known as tau inclusions and TDP-43 inclusions part of frontotemporal lobar degeneration (FTLD). Dan develops new, high-throughput postmortem methods to quantify changes to the arrangement and quantity of neurons and axons (cytoarchitecture and myeloarchitecture) to identify disease-specific patterns of microscopic degeneration and how they relate to macroscopic networks, cognitive decline, and in vivo biomarkers in the FTLD spectrum.